There are many users who use add-ins to heighten Outlook functionality. Fix 2: Open Outlook in the Safe Mode and Disable Add-ins Now, try to open the Outlook to check whether the issue is resolved.
Once the scanning gets completed, restart your computer. 
So, wait until the process the completed.
Now, the scan process will get started and will take some time. In the Command Prompt, type the given command and press the Enter key:. From the search result, right-click on the Command Prompt(Admin). Go to the Windows Search box and type cmd. You can perform this scan by doing the following: It is Windows in-built troubleshooting tool that scans for corrupted files and fixes them automatically. Hence, to check and fix the corrupted Windows system file, you can run the System File Checker(SFC) scan. If there are corrupted system files on your computer, then you might run into issues, and this might be the reason outlook is not opening on your Windows 10 computer. Fix 11: Delete Registry Key to Fix Outlook Not Opening In Windows 10 PC Issueįix 1: Run SFC Scan to Fix Outlook Won’t Open in Windows 10. Fix 9: Check if You Have Permissions to Access the PST File. Fix 8: Change DPI Settings to Fix Outlook Won’t Start Error. Fix 7: Delete the Outlook App Data Folder. Fix 5: Repair Outlook Data File to Resolve Outlook Will Not Open Issue. Fix 2: Open Outlook in the Safe Mode and Disable Add-ins. 
Fix 1: Run SFC Scan to Fix Outlook Won’t Open in Windows 10.
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